Infarct Size Reduction by Targeting Ischemic Injury
نویسندگان
چکیده
منابع مشابه
Reduction of myocardial infarct size by fluvastatin.
Statins have a variety of cardioprotective properties following chronic treatment. In contrast, little is known about the acute effects. Reperfusion acutely injures the heart by activation of neutrophils as well as endothelial cells. Because statins are known to influence the processes pathogenetically involved, we hypothesized that acute application of statins attenuates the sequelae of cardia...
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The importance of the activation of mitogen-activated protein kinases (MAPK) for the cardioprotection achieved by ischemic preconditioning (IP) is still controversial. We therefore measured infarct size and p38, extracellular signal-regulated kinase (ERK), and c-Jun NH(2)-terminal kinase (JNK) MAPK phosphorylation (by biopsies) in enflurane-anesthetized pigs. After 90 min low-flow ischemia and ...
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Ischemic heart disease is the leading cause of death and morbidity in the world, and ST-segment elevation myocardial infarction (STEMI) remains associated with a significant mortality rate and complications noted at 1-year follow-up, despite prompt coronary reperfusion achieved with either thrombolysis or primary percutaneous coronary intervention (PPCI). It is therefore clear that novel cardio...
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AIMS Reperfusion is mandatory to salvage ischaemic myocardium from infarction, but also induces additional reperfusion injury and contributes to infarct size (IS). Gentle reperfusion (GR) has been proposed to attenuate reperfusion injury, but this remains contentious. We now investigated whether (i) GR reduces IS and (ii) GR is associated with the activation of reperfusion injury salvage kinase...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2018
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.118.312939